Chemotherapy-induced peripheral neuropathy (CIPN) represents a major unmet medical need that currently has no preventive and/or curative treatment. This is, among others, driven by a poor understanding of the contributive role of drug transport across biological barriers to target-site exposure.
Time flies so fast. Time flies especially fast when you work together with such a fantastic team to improve the preclinical prediction of adverse effects of pharmaceuticals on the nervous system. With this meeting, our project comes to an end. One more reason to make this event something special.
Many psychotherapeutic drugs, including clozapine, display polypharmacology and act on GABAA receptors. Patients with schizophrenia show alterations in function, structure and molecular composition of the hippocampus, and a recent study demonstrated aberrant levels of hippocampal α5 subunit-containing GABAA receptors.
It was time again for a “Status of the Project” meeting. This time the consortium partners came together because we have been working on our objectives for 30 months. In order to enable our colleagues from overseas to participate, the online conference took place in the afternoon.
QSAR methods are widely applied in the drug discovery process, both in the hit‐to‐lead and lead optimization phase, as well as in the drug-approval process. Most QSAR algorithms are limited to using molecules as input and disregard pharmacophores or pharmacophoric features entirely.
Wednesday, February 24, 2021 – Thursday, February 25, 2021, @homeoffice. First things first: Despite the COVID-19 pandemic, we are – with some exceptions – on track and will have another …
The NeuroDeRisk Consortium proudly announces the launch of the NeuroDeRisk in silico Toolbox ! This computational toolbox consists of tools for screening chemical structures and drug candidates against a panel of neurotoxicophore …
It is as if the First Birthday of NeuroDeRisk was celebrated just yesterday and yet it was time for our 18-months meeting, which of course took place online. As always, it was a great pleasure to look into so many happy faces, even if the current situation around the COVID-19 pandemic unfortunately also delays …
Drug-induced Mood- and Cognition-related adverse events (MCAEs) are often only detected during the clinical trial phases of drug development, or even after marketing, thus posing a major safety concern and a challenge for both pharmaceutical companies and clinicians. To fill some gaps in the understanding and …
Monday, April 27, 2020 – Tuesday, April 28, 2020, @homeoffice. How time flies. Our project is already celebrating its very first anniversary. Normally, of course, we would have celebrated this …
